Abstract
Objective The aim of the study was to investigate the relationship between serum E-selectin (as a marker of endothelial activation) and vascular complications in children and adolescents with type 1 diabetes mellitus (T1DM). Participants and methods This was a case–control study including 30 children with T1DM (with mean age 10.8 years, disease duration 7.4 years) and 30 matched healthy controls. Serum E-selectin, glycosylated Hb (HbA1c), total cholesterol, and triglycerides (TG) were determined. Blood pressure and anthropometric parameters were also measured. Results Levels of serum E-selectin, cholesterol, and TG in patients were significantly higher than in controls; these levels were also higher in metabolically poorly controlled and albuminuric T1DM patients compared with metabolically well-controlled and nonalbuminuric T1DM patients. There was a positive correlation between serum E-selectin and HbA1c (r=0.9, P Conclusion We conclude that elevated biological markers of endothelial cell activation, such as serum E-selectin, may be related to vascular complications of DM, such as diastolic hypertension and microalbuminuria, in children with type 1 diabetes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
