Abstract
The cells of a chronic lymphocytic leukemia (CLL) and a prolymphocytic leukemia (PLL) formed rosettes with sheep red blood cells (SRBC) and expressed characteristic surface markers of B cells, i.e., monoclonal surface IgM, Ia-like antigen, and receptors for aggregated IgG. Rosette formation was demonstrated to be the result of binding activity of surface immunoglobulins to SRBC. Pretreatment of the leukemic cells with Pronase, or antibodies to μ, λ, or κ, chains, respectively, completely inhibited rosette formation with SRBC. Preincubation of SRBC with serum of IgM fraction of the patient with PLL decreased rosette formation demonstrating circulating antibodies to antigen(s) on SRBC. The serum and IgM fraction of the patient with CLL agglutinated and lysed SRBC. The antigen(s) on SRBC involved in rosette formation were not related to Forssman or Paul Bunnel antigen.
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