Abstract
Background: E-cadherin (epithelial-cadherin), encoded by the CDH1 gene, is a transmembrane glycoprotein playing a crucialrole in maintaining cell-cell adhesion. E-cadherin has been reported to be a tumor suppressor and to be down regulated ingastric cancer. Objective: The aim of this study is to find out the expression of E-cadherin in patients with gastric carcinoma and it's relation tohistological prognostic parameters. This study also aimed to investigate the morphological parameters of prognostic value:histologic type and tumor grading, depth of invasion, lympho-vascular invasion, perineural invasion and lymph node metastasis. Methods: This descriptive cross sectional study was carried out from March, 2015 to June, 2017 at the Department ofPathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The study materials were gastric tissue takenfrom 42 patients who underwent total or partial gastrectomy operation in Surgery Department of BSMMU and few privatehospitals and diagnosed as gastric carcinoma in Pathology department of BSMMU. Result: Among 42 cases, 26 were male and 16 were female with a male/female ratio of 1.6:1. Thirty two samples were totalgastrectomy specimen and twelve samples were partial/subtotal gastrectomy specimen. Ages of the patients ranged from 20 to76 years and the highest number(33.3%) of cases belonged to 50-59 years age group. This study showed E-cadherin expressiondid not show association with lymphovascular invasion, perineural invasion and depth of invasion. The rate of E-Cadherinpositivity shows association with histological type, histological grading and lymph node metastasis. Conclusion: Although alterations in E-cadherin and its expression may serve as promising biomarkers or therapeutic targets ingastric cancer but in this study E-cadherin expression was significantly more frequent in comparison with the histological type,histological grading and lymph node metastasis.
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