Abstract
Electrical stimulation of the E 36 (Zusanli) acupuncture point has shown beneficial effects for several inflammatory pathologies throughout the body and in the digestive system in particular. However, the mechanisms underlying this phenomenon are not well understood. Stimulation of E 36 (Zusanli) can result in a reduction in the level of proinflammatory cytokines. Similarly, stimulation of the vagus nerve is also able to reduce cytokine levels via the so-called “parasympathetic anti-inflammatory pathway”. Recent studies have shown that electroacupuncture of E 36 (Zusanli) leads to activation of the brainstem via signaling along the sciatic nerve and subsequent signaling to the adrenal glands via the vagus nerve. The ensuing anti-inflammatory effects are achieved via liberation of the dopamine neurotransmitter and subsequent activation of its D1 dopamine receptors in the adrenal glands. A deeper scientific understanding of the underlying mechanisms and the therapeutic effects of acupuncture confers greater confidence in this non-invasive, non-pharmacological, cost-effective method of electro-stimulating specific areas of the body to control inflammatory processes.
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