Abstract
(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acetic acid is one of the useful components of liquid crystal materials which can be produced through Williamson ether synthesis by synthesizing 4-hydroxy-cinnamic acid and 5-bromo-1-pentene. Although Williamson ether synthesis is generally slow under conventional external heating conditions, microwave irradiation was effective for significant acceleration of the etherification. Furthermore, we demonstrated the rapid and continuous synthesis of (E)-3-[4-(pent-4-en-1-yloxy)phenyl]acetic acid, using a microwave-assisted flow reactor developed by us, in which the blockage by salt precipitation was suppressed by the continuous addition of an aqueous methanol solution after the reaction cavity.
Highlights
Introduction(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylic acid is utilized as a component of liquid crystal materials [1]
Abstract: (E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acetic acid is one of the useful components of liquid crystal materials which can be produced through Williamson ether synthesis by synthesizing
3 was to precipitate quite for this Williamson ether synthesis carboxylate form of was found toThus, precipitate quite from the reaction mixture, when theThe solution wasto cooled to 3ambient temperature
Summary
(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylic acid is utilized as a component of liquid crystal materials [1] This compound is usually produced through Williamson ether synthesis by synthesizing. Flow chemistry has benefits in terms of safe on-demand synthesis, and various types of reactions have been demonstrated successfully in a continuous manner [10,11,12,13,14]. In this context, some flow-microwave systems have been reported [15,16].
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