Dysregulation of the hippo pathway in selective theca cell phosphatase and tensin homolog (tPten) mutant mice exhibiting a Polycystic Ovarian Syndrome (PCOS)-like phenotype

Abstract

Genome-wide association studies of patients with PCOS in multiple ethnic groups have consistently identified single-nucleotide polymorphisms of Yes-associated protein (YAP), a central player of the Hippo pathway, implicating that YAP may play a role in the pathophysiology of PCOS. The Hippo signaling pathway regulates cell growth and organ size through a kinase cascade that influences the activity of the transcriptional regulator YAP. Disruption of the Hippo pathway leads to the activation of YAP by reducing its phosphorylation leading to nuclear translocation.