Abstract
Genomic instability is a prominent feature in the development and progression of Multiple Myeloma (MM). The E3 ligase HUWE1 contributes to the regulation of genomic stability by promoting DNA damage tolerance during replicative stress. Previous studies, by our lab and others, have shown dysregulation of HUWE1 in MM. We have demonstrated an increase in expression of HUWE1 across plasma cell dyscrasias and HUWE1 has been reported as a mutational driver in t(11;14) myeloma. The aim of this study was to investigate the role of HUWE1 in DNA replication and explore whether dysregulation of HUWE1 contributes to genomic instability in MM.
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