Abstract
Objective: To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. Material and Methods: Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. Results: A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. Conclusions: Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.
Highlights
A neoplasm constituted by aberrant-looking mature neurons was Received: November 28, 2020
The abovementioned factors can be considered in the case reported of a very rare cerebellar tumor closely associated with a mutation of the PTEN gene
Mutation of the tumor suppressor gene PTEN, a gene located on the long arm of chromosome 10 (10q23), is the genetic alteration that characterizes Cowden syndrome, called multiple hamartoma syndrome [1] [2] [3]
Summary
A neoplasm constituted by aberrant-looking mature neurons was Received: November 28, 2020 Accepted: April 23, 2021 Published: April 26, 2021 observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. Conclusions: Verify the diagnosis of a rare entity, clearly related in scientific publications.
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