Abstract
Except for age, dyslipidemia is the most important predictive factor for coronary artery disease (1). The strong, independent, continuous, and graded relationship between total cholesterol (TC) levels, or low-density lipoprotein (LDL) cholesterol level and the risk of coronary artery disease (CAD) events has been clearly demonstrated world wide in men and women and in all age groups (2–6). High cholesterol levels are a major contributor to CAD: 38 million Americans have a TC of > 240 mg/dL and 96 million are estimated to have levels above 200 mg/dL (7). In general, a 1% increase in the LDL cholesterol level may lead to a 2–3% increase in CAD risk (3,4). Aggressive lipid-lowering drug treatment in high-risk individuals will reduce coronary heart disease (CHD) morbidity and mortality rates and increase overall survival (8–12).
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