Dyslipidemia in the Russian Federation: population data, associations with risk factors

N I Belova,N S Karamnova,L I Gomanova,E M Filichkina,E I Yamashkina,L L Shagrov,A L Borisova,Yu I Ragino,O R Aslyamov,I N Baryshnikova,A E Imaeva,N A Imaeva,S E Evstifeeva,E B Dorzhieva,A V Kudryavtsev,E B Yarovaya,S A Maksimov,M V Esina,M A Samotrueva,M M Isakhanova,G V Khokhlova,A M Nikitina,B M Nazarov,E A Naumova,I A Efimova,Yu Yu Shamurova,I A Levina,A A Keskinov,A S Tokareva,N V Savvina,M S Pokrovskaya,M G Ataev,Yu V Doludin,V A Kutsenko,T O Gonoshilova,A A Rodionov,G I Simonova,S A Shalnova,Yu E Spiridonova,T A Kunyaeva,I A Khakuasheva,M B Kotova,O A Litinskaya,G A Muromtseva,A V Kapustina,V S Yudin,V K Kurashin,A V Solovyova,G E Svinin,T V Repkina,E Z Urbanova,N Yu Borovkova,E N Chernysheva,Yu A Balanova,L V Elgarova,E A Shirshova,V N Nikulin,M A Umetov,M O Radjabov,V S Shramko,O M Drapkina,I V Tantsyreva,S V Glukhovskaya,S M Yudin,A L Yasenyavskaya,O E Ivlev,A V Kontsevaya,O V Kryachkova

doi:10.15829/1728-8800-2023-3791

Abstract

Aim. To study the prevalence of dyslipidemias and their association with various risk factors in the Russian population of men and women aged 35-74 years in 2020-2022.Material and methods. This work was carried out as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study. The sample included 28731 men and women aged 35-74 years living in 15 Russian regions. Hypercholesterolemia (HC) was diagnosed with total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein cholesterol (LDL-C) was considered ≥3,0 mmol/l, hypertriglyceridemia — with triglyceride levels ≥1,7 mmol/l, reduced high-density lipoprotein cholesterol (HDL-C) <1,0 mmol/l in men and <1,2 mmol/l in women. Associations were assessed using logistic regression after adjustment for socio-demographic characteristics, drinking status, presence of hypertension (HTN) and stroke.Results. The prevalence of hypertriglyceridemia in the Russian Federation in 2020-2022 was 58,8%, hypertriglyceridemia — 32,2%. The incidence of lipid-lowering therapy increased with age from 1% in the group of 35-44 years to 16% in the group of 65-74 years. On average, only 7,6% of study participants received lipid-lowering therapy. Significant associations of HC with HTN, obesity and alcohol abuse were identified. Similar results were obtained for elevated LDL-C levels, with the exception of alcohol abuse. In turn, a reduced HDL-C level was significantly associated with the lack of higher education, marriage, physical activity, smoking and the presence of diseases.Conclusion. The prevalence of lipid disorders in the Russian Federation in 2020-2022 remained at a high level. These disorders occurred more often in women, and they were better informed about their cholesterol levels and more often received lipid-lowering therapy. HTN, obesity, and some behavioral and social risk factors were associated with dyslipidemia.

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