DYSLIPIDEMIA IN SUBCLINICAL HYPOTHYROIDISM IN TERTIARY HEALTH CARE CENTRE

Abstract

BACKGROUND: Subclinical hypothyroidism is dened as normal serum Total T4 /free T4 and Total T3 /free T3 levels in the presence of raised serum thyroid stimulating hormone (TSH) levels. The association between subclinical hypothyroidism and dyslipidemia has been widely investigated, but the ndings remain controversial. To assess lipid AIM AND OBJECTIVE: abnormalities in patients diagnosed with subclinical hypothyroidism. A cross se MATERIALS AND METHODS: ctional study was carried out in 100 patients of subclinical hypothyroidism at Rama Medical College Hospital and Research Centre. Blood samples were collected and analysed for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total cholesterol, serum triglycerides, low-density lipoproteincholesterol (LDL), and high-density lipoprotein-cholesterol (HDL). In this study total RESULTS: cholesterol (TC) was signicantly elevated (p value <0.05) in patients with subclinical hypothyroidism. Triglycerides (TG) and low density lipoprotein cholesterol (LDL) were also high in these patients but the difference was not statistically signicant. High density lipoprotein cholesterol (HDL) was signicantly reduced. CONCLUSION: SCH is associated with dyslipidemia, increased total cholesterol, TG, LDL, and decreased HDL are observed. We strongly recommend biochemical screening for thyroid dysfunction for all patients with dyslipidemia.