Dyslipidemia in psoriasis patients: a case-control study

Abstract

<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic inflammatory disorder with defective proliferation and differentiation of keratinocytes. It is associated with metabolic syndrome i.e. dyslipidemia, hypertension, obesity, cardiovascular diseases and insulin resistance. The high incidence of cardiovascular events in psoriasis is highly associated with abnormal lipid metabolism. This case-control study was done in North Indian medical institute to investigate the levels of serum lipids in psoriasis patients taking in account various parameters like weight, height, body mass index, blood pressure and diabetes.</p><p class="abstract"><strong>Methods:</strong> We assessed the fasting lipid profile in 48 psoriasis patients and 48 healthy, age and sex matched controls.<strong></strong></p><p class="abstract"><strong>Results:</strong> The study found significant elevation (p<0.05) of serum total cholesterol, triglycerides, low density lipoproteins (LDL) and very low density lipoproteins (VLDL) in psoriasis patients compared to controls. The levels of high density lipoproteins (HDL) were also significantly lower (p<0.05) in psoriasis patients.</p><p class="abstract"><strong>Conclusions:</strong> This study suggests that psoriasis is a high risk disorder for cardiovascular mortality and morbidity because of its association with dyslipidemia.</p><p> </p>