Dyslipidemia in HIV infected and AIDS patients: Association of serum lipids with HIV status, a cross-sectional study

Abstract

Context and Aim: Hematological abnormalities are among the most common complications of infection with human immunodeficiency virus (HIV). There have been quite a few studies on the alterations in lipid profile, too, although the results have largely been inconclusive. The present study was carried out to assess CD4 cell counts and lipid profile in the HIV-infected and AIDS patients in the Indian population and correlate them with the seronegative controls. Materials and Methods: The present study was designed as a cross-sectional, hospital-based study conducted between January 2017 to September 2017 to assess CD4 cell counts and lipid profile in the HIV-infected and AIDS patients in the Indian population and correlate them with the seronegative controls. Evaluation of lipid profile was done using Erba EM 360, an automated analyzer powered by a diffraction grating photometer, whereas CD4 cell counts were evaluated using Partec Cyflow Counter. Statistical Analysis: The data was analyzed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA). Comparison of the said parameters was done using analysis of variance and post hoc Games-Howell test. P value of <0.05 was considered statistically significant. Results: The levels of total cholesterol and low-density lipoproteins (LDLs) were significantly decreased whereas triglycerides and very LDLs were significantly increased in the HIV-infected and AIDS patients when compared with the seronegative controls. Conclusion: Total cholesterol, LDLs, triglycerides, and very LDLs were significantly altered in the HIV-infected and AIDS patients when compared with the seronegative controls.