Dyslipidemia acts as a close link between cardiovascular risk and renal progression in nephrotic children

Abstract

Background: Hyperlipidemia (HLP) is one of the cardinal manifestations of primary nephrotic syndrome (PNS). More importantly, HLP appears to act as a close link between cardiovascular risk and renal progression in nephrotic children. However, until recently, little information based on clinical and biochemical evidence was available to support this hypothesis. Objective: We investigated the linkage between cardiovascular risk and renal progression of nephritic syndrome in children. Methods: Three hundred seventy eight PNS children and 200 healthy volunteers were recruited into this study. Fasting serum levels of lipoprotein (a) [Lp(a)], cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Serum LDL and estimate glomerular filtration rate (eGFR) were calculated by the Friedewald formula and the Schwartz formula respectively. Results: Serum concentrations of Lp(a), TC, TG, HDL, LDL, and apoB were higher in the PNS than in the control group (p Conclusions: Lipid abnormalities may parallel with the reduction in renal function. On the other hand, the upregulations of serum lipid profiles, especially to Lp(a) and TG levels, can indeed accelerate cardiovascular risk in PNS children. Keywords: Cardiovascular risk, chronic kidney disease, estimate glomerular filtration rate, lipid profiles, primary nephrotic syndrome