Dyslipidaemia was correlated to the posterior circulation infarction in non-diabetic populations

Yun Luo,Jingwei Li,Zheng Li,Jiahui Zhang,Zhengjuan Lu

doi:10.1186/s12944-018-0799-0

Abstract

BackgroundDiabetes mellitus (DM) was prone to happening in posterior circulation infarction (POCI) and DM also has the impact on the lipids, our study was to investigate the correlation between lipid compositions and POCI.MethodsData was collected from the patients with acute ischemic stroke (AIS) hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012. Lipids and other risk factors in the different populations were investigated in relation to occurrence of POCI based on the infarction location.ResultsSix hundred ten patients with AIS were included in this study, which had 428 with anterior circulation infarction (ACI) and 182 with POCI. Elevated Triglyceride (TG) and decreased High density lipoprotein cholesterol (HDL-C) were seen in the POCI of total populations and AIS without DM compared to the ACI, but not in the populations of AIS with DM, so did the elevated TG/HDL-C ratios. Also, the percent of low HDL-C level and high TG level were higher in POCI group than that in ACI group. Furthermore, single factors logistic regression demonstrated that TG, HDL-C and TG/HDL-C ratio were correlated to the POCI whatever in the total populations or AIS without DM, but this kind of trend just maintained in the populations of AIS without DM after adjusting by relative interference factors.ConclusionDyslipidaemia was prone to happening in POCI compared to ACI in the non-diabetic populations, which was correlated to the pathogenesis of POCI.

Highlights

Diabetes mellitus (DM) was prone to happening in posterior circulation infarction (POCI) and DM has the impact on the lipids, our study was to investigate the correlation between lipid compositions and POCI
Risk factors of POCI compared to the anterior circulation infarction (ACI) There was 29% of DM in the ACI, while 42.9% in the POCI, the difference was significant (P = 0.001), the same trend was existed in hypertension and blood glucose (BG)
We found that TG/High density lipoprotein cholesterol (HDL-C) ratios was higher in the POCI compared to the ACI both in the total and non-diabetic populations, which demonstrated that dyslipidaemia played the more important role on POCI (Fig. 2)

Summary

Introduction

Diabetes mellitus (DM) was prone to happening in posterior circulation infarction (POCI) and DM has the impact on the lipids, our study was to investigate the correlation between lipid compositions and POCI. As the important risk factors of AIS, diabetes mellitus (DM) had obvious impact on both of subtypes, but DM was more prone to linked with POCI [1], which was identified in many studies include ours (Article in Chinese) [2,3,4]. Diabetes mellitus had obvious impact on the lipids, which mainly reflects in the rise of Triglyceride (TG) and fall of High density lipoprotein cholesterol (HDL-C) [6, 7]. Both the blood glucose and lipids would play the important role on the occurrence of arteriosclerosis, while lipids would play the more direct role [8, 9]. Did this mean that the induction of arteriosclerosis and ischemic stroke by DM was through lipids, and this was proved in our previous study, that was, low level of HDL-C was correlated to

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Conclusion