Abstract
Experimental steroid myopathy was induced in rabbits by injections of triamcinolone acetonide. Sarcoplasmic reticulum was prepared from quadriceps muscle. Calcium-dependent ATPase activity decreased in the steroid-treated group. Calcium uptake and binding of sarcoplasmic reticulum were also reduced in the steroid-treated group. By the same methods, sarcoplasmic reticulum in human steroid myopathy was analysed. Again, decreased calcium-dependent ATPase activity, calcium uptake, and binding were revealed in steroid myopathy. These results are consistent with the view that the effects of glucocorticoid on skeletal muscle are mediated, in part, through its action on the calcium transport system.
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