Year-end Sale % OFF 
Abstract
Obesity is inseparably connected with oxidative stress. This process may disturb the functioning of the oral cavity, although the effect of oxidative stress on salivary gland function and changes in the qualitative composition of saliva are still unknown. Our study is the first to evaluate salivary redox homeostasis in 40 overweight and obese adolescents and in the age- and gender-matched control group. We demonstrated strengthening of the antioxidant barrier (↑superoxide dismutase, ↑catalase, ↑peroxidase, ↑uric acid, ↑total antioxidant capacity (TAC)) with a simultaneous decrease in reduced glutathione concentration in saliva (non-stimulated/stimulated) in overweight and obese teenagers compared to the controls. The concentration of the products of oxidative damage to proteins (advanced glycation end products), lipids (malondialdehyde, 4-hydroxynonenal) and DNA (8-hydroxydeoxyguanosine) as well as total oxidative status were significantly higher in both non-stimulated and stimulated saliva as well as plasma of overweight and obese adolescents. Importantly, we observed more severe salivary and plasma redox alterations in obese adolescents compared to overweight individuals. In the study group, we also noted a drop in stimulated salivary secretion and a decrease in total protein content. Interestingly, dysfunction of parotid glands in overweight and obese teenagers intensified with the increase of BMI. We also showed that the measurement of salivary catalase and TAC could be used to assess the central antioxidant status of overweight and obese adolescents.
Highlights
Overweight/obesity is a social problem worldwide, characterized by an increase in body weight that results in excessive accumulation of fat [1]
Stimulated secretion was significantly lower in the group of overweight and obese adolescents compared to the controls (↓40%, p < 0.0001; ↓51%, p < 0.0001, respectively)
We noted a significant increase of Total oxidant status (TOS) in non-stimulated and stimulated saliva in obese adolescents compared to the overweight group, but observed no such dependence for Total antioxidant capacity (TAC) and antioxidant enzymes
Summary
Overweight/obesity is a social problem worldwide, characterized by an increase in body weight that results in excessive accumulation of fat [1]. We have observed a steady growth in the frequency of overweight and obesity, observed among adults, and children and adolescents [2]. This results from various genetic, environmental and economic (easy access to cheap and highly calorific food) factors as well as evolutionary conditioning (sedentary lifestyle, low physical activity, low energy expenditure) [1,3]. Studies have shown that about 40% of overweight children will continue to gain weight during the puberty period, and about 80% of these obese teenagers will remain obese as adults [5]. Obesity rates are higher in developed countries, more overweight or obese children live in developing countries, and this trend applies to European countries
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
