Dysfunction of bulbar central pattern generator in ALS patients with dysphagia during sequential deglutition

Abstract

Objective The aim of this study is to investigate a probable dysfunction of the central pattern generator (CPG) in dysphagic patients with ALS. Methods We investigated 58 patients with ALS, 23 patients with PD, and 33 normal subjects. The laryngeal movements and EMG of the submental muscles were recorded during sequential water swallowing (SWS) of 100 ml of water. The coordination of SWS and respiration was also studied in some normal cases and ALS patients. Results Normal subjects could complete the SWS optimally within 10 s using 7 swallows, while in dysphagic ALS patients, the total duration and the number of swallows were significantly increased. The novel finding was that the regularity and rhythmicity of the swallowing pattern during SWS was disorganized to irregular and arhythmic pattern in 43% of the ALS patients. The duration and speed of swallowing were the most sensitive parameters for the disturbed oropharyngeal motility during SWS. Conclusions The corticobulbar control of swallowing is insufficient in ALS, and the swallowing CPG cannot work very well to produce segmental muscle activation and sequential swallowing. CPG dysfunction can result in irregular and arhythmical sequential swallowing in ALS patients with bulbar plus pseudobulbar types. Significance The arhythmical SWS pattern can be considered as a kind of dysfunction of CPG in human ALS cases with dysphagia.