Dysembryoplastic neuroepithelial tumor (DNET): Possible link to maternal hypothyroidism?

Abstract

Event Abstract Back to Event Dysembryoplastic neuroepithelial tumor (DNET): Possible link to maternal hypothyroidism? J. Rovet1, 2*, J. Skocic1 and E. Widjaja1 1 The Hospital for Sick Children, Canada 2 University of Toronto, Canada Rodent research shows maternal hypothyroidism tips the balance between oligodendrocytes and astrocytes in the offspring favouring astrocytes (Sharlin et al, 2008). DNETs are rare, benign glioneuronal tumors. We report here clinical and neuroimaging findings on a 10 year old female, PE, studied since birth in an ongoing study of offspring of hypothyroid women. In infancy, PE was described as socially engaging and having average cognitive abilities relative to offspring of non-hypothyroid women. At age five, she exhibited exceptional performance on most cognitive tasks but was argumentative, confrontational, emotional, and had impulse control issues. Newly acquired behavioural problems included aggression towards siblings and explosive outbursts. At age 10, behavioural and executive functioning problems persisted while neuroimaging findings indicated a large DNET in the left middle frontal gyrus. Diffusion Tensor Imaging studies of PE’s left and right frontal lobes indicated that relative to the contralateral region, the DNET showed reduced fractional anisotropy (FA) and increased diffusivity (MD), thus signifying damaged microstructure. Additional comparisons revealed reduced FA and increased MD in left frontal lobe compared with age and sex matched offspring of hypothyroid and nonhypothyroid women. We question whether the DNET arises from maternal hypothyroidism during pregnancy or is an incidental finding. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Frontal Lobe Development Citation: Rovet J, Skocic J and Widjaja E (2010). Dysembryoplastic neuroepithelial tumor (DNET): Possible link to maternal hypothyroidism?. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00076 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2010; Published Online: 29 Jun 2010. * Correspondence: J. Rovet, The Hospital for Sick Children, Toronto, Canada, Joanne.Rovet@sickkids.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers J. Rovet J. Skocic E. Widjaja Google J. Rovet J. Skocic E. Widjaja Google Scholar J. Rovet J. Skocic E. Widjaja PubMed J. Rovet J. Skocic E. Widjaja Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.