Abstract
In this work we have studied the dynorphin convertase (DCE) in cerebrospinal fluid (CSF) collected from patients with different states of chronic pain. The assessment of the enzyme activity was accompanied with measurements of the CSF level of prodynorphin derived opioid peptides. In CSF from patients with fibromyalgia the DCE activity was found to be significantly decreased as compared to that of control samples. In contrast a significant increase was found for the level of immunoreactive dynorphin A. In CSF from patients with idiopathic pain a significant negative correlation between all prodynorphin derived peptides and DCE activity was observed. The results suggest a regulatory function on the peptide level of the dynorphin convertase
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