Abstract
Objective To investigate the dynamic expression of Nogo-A receptor （NgR） in the hippocampus following focal cerebral ischemia in rats. Methods The focal cerebral isehemia model was established by electrocoagulating the right middle cerebral artery in rats. The expression of NgR in the ischemic hippocampal CA1, CA2 and CA3 regions at different time points after cerebral isehernia were detected by inmaunohistoehemical staining. Results The expressions of NgR were up-regulated in hippoeampal CA1 and CA2 regions at the first day, in the CA3 region at the second day after cerebral isehemia; the expressions of NgR in the CA1 and CA2 regions at the fifth day was decreased to the lowest. The expressions of NgR was up-regulated again in the CA1 and CA2 regions at the 28th day. Conclusions The NgR expression in the hippocampus in isehemie side showed different change characteristics at different regions, however, the overall change trend showed a ＂2 peaks and a valley＂ phenomenon, which indicated that NgR might have different functions at different time periods after cerebral isehemia. Key words: Brain ischemia; Nogo protein; Receptors, cell surface; Hippocampus; Rats
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