Abstract
Background/Purpose: Combating Antibiotic resistance has become a great challenge for clinicians due to inappropriate use of antibiotics. Antibiotics once considered being magic bullet is no more having that title. Recommendation in AMR situation in by Department of Biotechnology (DBT) and Treatment Guidelines for Antimicrobial Use by Indian Council of Medical Research (ICMR) India emphasized the need for regional surveillance starting from the level of state to an individual hospital has been motivation behind the study. Method: Three hospitals in region of Cuddalore in Tamilnadu (India) have been the source of specimen for isolation of Escherichia coli during the period of January to July 2017. Antibiogram reports were collected during the study period and utilized for the study. Result: Among 124 isolates Urine, High vaginal swab, Pus, Serum, Oral swab and Amniotic fluid occupied 81.45%(n-101), 08.06%(n-10), 5.64%(n-7), 2.41%(n-3), 1.62%(n-2) and 0.81%(n-1) respectively. Antibiogram for the Escherichia coli isolates revealed 90% of resistance to Cefepime, 68% to Ciprofloxacin, 50% to Tetracyclin, 30% to Meropenum etc., Similarly high percentage of sensitiveness was evident in Cefotaxime (95.94%), Imipenum (95.91%), Piperacillin/Tazobactem (86%), Meropenum (70%) etc. Conclusion: On comparison with the 2014 ICMR (Antimicrobial Susceptibility) data percentage of resistance and susceptibility has a drastic change both in resistance and sensitivity. From the study it is clear that the generic recommendations on antibiotic use at national level can't be a desirable solution or recommendations to clinicians. The study signifies the importance of local surveillance and infection control programs. Funding Statement: No funding was obtained for this study. Declaration of Interest: The authors report no conflict of interest. Ethics Approval Statement: The samples were not collected exclusively for this study, and since it is a retrospective study where we have analysed the sensitivity pattern of the isolates in reference to ICMR-Antimicrobial use guidelines. Similarly international guidelines such as Consolidated Standards of Reporting trials (CONSORT) and uniform requirements for manuscripts submitted to biomedical journals(URM) states that ethics approval is required when animal or human are to be used for teaching or new intervention research. Since our study is not coming under prospective randomised trials we have not gone for Ethical clearance.
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