Abstract
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.
Highlights
Dynamin is a 100-kDa GTPase [1, 2] that controls a variety of vesicular budding events including synaptic vesicle recycling, receptor-mediated endocytosis, caveolae internalization, phagocytosis, and secretory vesicle budding from the transGolgi network [3,4,5,6,7,8,9]
We report that dynamin-2 interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is associated with the postsynaptic density
We report here that dynamin-2 interacts with at least two members of the Shank/ProSAP family, which have recently been described as components of the postsynaptic density (PSD) [34, 35] Dynamin-2 exhibits a synaptic distribution in cultured hippocampal neurons and is enriched relative to dynamin-1 in the postsynaptic density
Summary
Dynamin is a 100-kDa GTPase [1, 2] that controls a variety of vesicular budding events including synaptic vesicle recycling, receptor-mediated endocytosis, caveolae internalization, phagocytosis, and secretory vesicle budding from the transGolgi network [3,4,5,6,7,8,9]. We report that dynamin-2 interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is associated with the postsynaptic density. We report here that dynamin-2 interacts with at least two members of the Shank/ProSAP family, which have recently been described as components of the postsynaptic density (PSD) [34, 35] Dynamin-2 exhibits a synaptic distribution in cultured hippocampal neurons and is enriched relative to dynamin-1 in the postsynaptic density.
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