Abstract
Different changes in vagal chronotropic effects were observed in cats under blockade of various types of muscarinic cholinergic receptors. Burst stimulation of the vagus nerve caused synchronization of the vagal and cardiac rhythms, which was potentiated by M1 and M3 receptor antagonists and suppressed by the M2 blocker gallamine. The components of the vagal chronotropic effect showed different sensitivity to selective M-cholinolytics.
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