Abstract
The dynamics of TL antigens on the surfaces of normal thymus cells and leukemia cells has been studied. Immunofluorescence studies show (i) TL antigens can be capped by anti-TL antibodies, although no detectable microprecipitation (spotting) occurs (ii) a spontaneous loss of TL antigens and a lack of reexpression after capping of TL antigens on thymus cells in culture, though under the same culture conditions they normally reexpress H-2, and (iii) leukemia cells do not spontaneously lose their TL antigens in culture, but they slowly cap and become depleted of TL when cultured in the presence of anti-TL antibodies. Leukemia cells, in contrast to TL + thymocytes, do reexpress their TL antigens after capping. The fundamental mechanism of capping is reconsidered in view of the exceptional behavior of TL-anti-TL complexes, and a new hypothesis is suggested.
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