DYNAMICS OF THE INCIDENCE AND MORTALITY OF COLON CANCER IN 2000-2010 IN ARKHANGELSK REGION (POPULATION STUDY)

Abstract

Objective. To give medical and ecological evaluation for the epidemiology of colon cancer (CC) between 2000 and 2010 in Arkhangelsk oblast (AO) by the data of regional population cancer registry (ARCR). Materials and methods. Data on all cases of CC (C18.0-C18.9) in the AO in 2000-2010 were extracted from the database of the ARCR. The incidence and mortality from CС by sex, age, place of residence and tumor location studied. Adjustment for age was performed using WHO 2000 age standard. Data on population number were extracted from Arkhangelskstat. Results. Over the study period, 3267 cases of the CC were registered. Crude and standardized CC incidence increased during the period by 44.3% and 27.44, respectively. Mortality from CC in 2010 was 12.5 per 100 000 population. Epidemiological indicators are higher than in average in Russia, showing the same dynamics. Probability to get CC progressively elevates with age accounting 5.5 and 8.1 vs 190.3 and 142.3 per 100 000 male and female population at age 40-49 vs 70 years and older, respectively. Crude CC incidence in AO is higher in the female population while standardized one was higher among males. This is explained by a much smaller proportion of the males in older age groups and confirms the importance of standardization. The CC incidence rates are lower in rural population comparatively to urban one. Levels and trends of CC incidence among inhabitants of cities with pulp and paper plants were similar to that in other cities of AO. Conclusions. Epidemiological model for CC in both AO and Russia in whole shows progressively increasing incidence and mortality with relatively small gap between them and substantially differs from that in developed countries. Pulp and paper industry does not influence on CC incidence.