Dynamics of prooxidant and antioxidant homeostasis rates in patients with lichen ruber planus in the process of complex treatment

Abstract

Objective — to determine and analyze the dynamics of the parameters of prooxidant antioxidant homeostasis and those of endogenous intoxication in patients with lichen ruber planus (LRP) when used in the complex treatment of antioxidant and laser therapy.Materials and methods. 95 patients with LRP were observed, of which 31 patients (I comparative group) received standardized treatment, 32 patients (II comparative group) additionally received an anti­oxidant drug quercetin and 32 patients (III — main group) additionally received antioxidant and low­intensity laser therapy (arterial laser irradiation of blood) in which the blood content was determined before and after treatment: malonic aldehyde (MA), fractions of oxidative modification of neutral (OMB E370) and basic (OMB E430) proteins, average weight molecules (AWM), reduced glutathione (RG), catalase (CA) and ceruloplasmin (CP).Results and discussion. Prior to initiation of therapy, patients with LRP showed a significant increase in levels of MA (in plasma and erythrocytes), serum fractions of OMB E370 and OMB E430 as well as AWM in the background of decrease in RG and CP. The standard treatment of patients of I group has led to a decrease in the level of RG. The additional use of the drug with antioxidant action in ІІ group has resulted in a decrease in levels of MA and OMB E370. The patients of III group (the main one), who additionally received antioxidant and laser therapy, showed substantially decreased levels of MA, OMB E370, OMB E430 and AWM, as also increased levels of RG and CP as compared with those of the control group and of the I and II comparative groups after treatment.Conclusions. Patients with LRP had a substantial increase in the parameters of the prooxidant system of blood in the background of the reduction of certain indicators of the antioxidant system. Inclusion of an antioxidant drug in the complex treatment of LRP contributes to a decrease in certain parameters of the prooxidant system of blood, while the combined use of antioxidant and low­level laser therapy contributes to normalization or a tendency to normalization of the parameters of both the prooxidant and antioxidant blood systems.