Abstract
Dynamics of proinflammatory (IL-1, TNF), immunoregulatory (IL-4) and anti-inflammatory (IL-10) cytokine levels was studied in 35 and 6 patients with abdominal fever with outcome of the disease in recovery and acute bacterial carriage, respectively. Level of cytokines in peripheric blood was studied at the height of the disease (the second week) and at the stages of early (the fourth week) and late (before hospital discharge) convalescence. Control group included 24 healthy individuals. At the height of the disease IL-1 and TNF levels were significantly higher in patients with disease recovery compared to patients with acute bacterial carriage. Dynamics of indices of anti-inflammatory cytokines IL-4 and IL-10 in patients with acute abdominal fever with outome in recovery and acute bacterial carriage was similar: the indices were increased at the height of the disease, at the stages of early and late convalescence the stable tendency to further increase was observed. Dynamics of proinflammatory (IL-1 and TNF) cytokines demonstrates that chronization of infectious process in abdominal fever/development of acute bacterial carriage is specified by insufficient increase of proinflammatory cytokines.
Highlights
Dynamics of proinflammatory (IL-1, TNF), immunoregulatory (IL-4) and anti-inflammatory (IL-10) cytokine levels was studied in 35 and 6 patients with abdominal fever with outcome of the disease in recovery and acute bacterial carriage, respectively
Level of cytokines in peripheric blood was studied at the height of the disease
TNF levels were significantly higher in patients with disease recovery compared to patients
Summary
ДИНАМИКА ПОКАЗАТЕЛЕЙ ЦИТОКИНОВ (IL-1, TNF, IL-4, IL-10) В ПРОЦЕССЕ ФОРМИРОВАНИЯ РАЗЛИЧНЫХ ИСХОДОВ БРЮШНОГО ТИФА. Резюме У 35 больных брюшным тифом с исходом заболевания в выздоровление и у 6 больных с исходом в острое брюшнотифозное бактерионосительство изучена динамика изменений уровней провоспалительных (IL-1, TNF), иммунорегуляторных (IL-4) и противовоспалительных (IL-10) цитокинов. У больных с острым течением брюшного тифа с исходами заболевания в выздоровление в период разгара болезни уровни главных провоспалительных цитокинов (IL-1 и TNF) были значительно выше, чем в группе больных с исходом в бактерионосительство. У обеих групп больных с острым течением брюшного тифа с исходами заболевания в выздоровление и в формирование острого брюшнотифозного бактерионосительства изменения уровней IL-4 и IL-10 имели схожую динамику: показатели повышались в период разгара, а в периоды ранней и поздней реконвалесценции имели стойкую тенденцию к дальнейшему повышению.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
