Abstract
The dynamic properties of two BODIPY labeled phospholipid molecules in micellar systems have been studied with two different spectroscopic techniques, which provide complementary information (fluorescence correlation spectroscopy (FCS) and time-resolved fluorescence anisotropy (TRFA), respectively). One phospholipid had the fluorescent probe attached to the headgroup (abbreviated as head-labeled) and the other one had the probe at the acyl chain at the sn-2 position of the phospholipid (abbreviated as tail-labeled). From FCS experiments, the translational diffusion constant, aggregation number and hydrodynamic size of the micelles were determined. The micelles were larger in size than reported in the literature, which is due to the incorporation of the relatively large sized fluorescent probe. The FCS results were confirmed by the results of dynamic light scattering experiments on both empty micelles and micelles containing the fluorescent lipid probe. Both results showed that the probe has a very signifi...
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