Abstract
One trend in the design of atomic power stations (APS) based on fast neutrons is the development of APS in which dissociating nitrogen tetroxide is used as heat carrier and as working heat. Here, the authors study the combined action of ionizing radiation and of sodium nitrite on methemoglobin formation associated with the action of nitrites as a metabolic product of nitrogen oxide metabolism. Experiments were carried out on male Wistar rats weighing 180-200 g. Single whole-body irradiation was given on the UGU-420 gamma-ray source in doses of 77.4 and 180.6 mCi/kg body weight. The dynamics of changes in the methemoglobin concentration was monitored on a VSU-2-P spectrophotometer at 540-630 nm. A diagram showing the relationship between nitrite-induced methemoglobin formation and dose and time elapsing after irradiation is shown.
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