Abstract
Myosin-X (Myo10) is an unconventional myosin that localizes to the tips of filopodia, has potent filopodia inducing activity, and is also required for proper spindle orientation. The Myo10 heavy chain consists of a myosin motor domain, 3 IQ motifs, and a complex tail that includes an alpha helical region, 3 PH domains, a MyTH4 domain, and a FERM domain. One of the PH domains binds to the important signaling lipid PIP3, the MyTH4 domain can bind to microtubules, and the FERM domain can bind to the cytoplasmic domain of B-integrins.
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