Abstract
Developing a novel drug delivery system is critical in managing and treating a broader spectrum of diseases. The intensified demand for an effective targeting carrier has led to rapid development and a better understanding of the principles of forming polymeric micelles. Micelles exist in a state of dynamic equilibrium. Henceforth, the dynamics involved in the formation of micelles have become obligatory to understand. This chapter deals with the underlying parameters influencing micelle development and the simulation methods. The advent of analytical tools such as fluorescence resonance energy transfer (FRET) and dissipative particle dynamics (DPD) will help in ascertaining the micellar dynamics in a much more effective manner. Various theories and energetics involved in micelle formation have been deliberated.
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