Abstract
Introduction: During the last decade, infraslow magnetoencephalography (DC-MEG) has been refined and thus allows to record and investigate slow cortical activity in the infraslow frequency range (<0.1Hz) non-invasively. In combination with time-resolved Near-Infrared-Spectroscopy (tr-NIRS), the basic physiology of neurovascular coupling can be characterized, i.e. the dynamics and interrelation of neuronal activity and the concomitant vascular/metabolic changes. As shown here, in extension to recent modulation-based MEG recordings unmodulated DC-MEG allows to analyse neurovascular physiology not only in the low frequency range but also simultaneously up to the millisecond range which is important in particular at the beginning of activation.
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