Abstract
Recent studies indicate that cardiovascular regulation is impaired and sympathetic activity is abnormally elevated in patients with obstructive sleep apnea (OSA) during both wakefulness and sleep1,2. Heart rate variability (HRV) has been found to be substantially reduced in OSA3. Spectral analysis shows an increase in the proportion of low-frequency (0.04 to 0.15 Hz) content relative to high-frequency (0.15 to 0.4 Hz) content of heart rate oscillations in awake OSA subjects, suggesting increased sympathetic modulation along with decreased vagal cardiac activity. Although statistical and spectral analyses of HRV offer a simple and non-intrusive means of assessing cardiovascular autonomic function in these subjects, the measures derived can be confounded significantly by intra-and inter-subject differences in ventilation level and breathing pattern4,5. To circumvent this limitation, we have introduced a minimal modeling approach that allows a clear delineation of the respiratory-related influences on HRV from the effects that are intrinsically circulatory in nature.KeywordsObstructive Sleep ApneaHeart Rate VariabilityImpulse ResponseMinimal ModelBreathing PatternThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
