Dynamics of gamma-band activity in human magnetoencephalogram during auditory pattern working memory

Abstract

Both electrophysiological research in animals and human brain imaging studies have suggested that, similar to the visual system, separate cortical ventral “what” and dorsal “where” processing streams may also exist in the auditory domain. Recently we have shown enhanced γ-band activity (GBA) over posterior parietal cortex belonging to the putative auditory dorsal pathway during a sound location working memory task. Using a similar methodological approach, the present study assessed whether GBA would be increased over auditory ventral stream areas during an auditory pattern memory task. Whole-head magnetoencephalogram was recorded from N = 12 subjects while they performed a working memory task requiring same–different judgments about pairs of syllables S1 and S2 presented with 0.8-s delays. S1 and S2 could differ either in voice onset time or in formant structure. This was compared with a control task involving the detection of possible spatial displacements in the background sound presented instead of S2. Under the memory condition, induced GBA was enhanced over left inferior frontal/anterior temporal regions during the delay phase and in response to S2 and over prefrontal cortex at the end of the delay period. γ-Band coherence between left frontotemporal and prefrontal sensors was increased throughout the delay period of the memory task. In summary, the memorization of syllables was associated with synchronously oscillating networks both in frontotemporal cortex, supporting a role of these areas as parts of the putative auditory ventral stream, and in prefrontal, possible executive regions. Moreover, corticocortical connectivity was increased between these structures.