Abstract
It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF). The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofilm samples from the palate, oral floor and cheeks were collected. All subjects brushed their teeth with toothpaste containing AmF or NaF. Specimens were collected before, as well as immediately after and at 30 and 120 minutes after tooth brushing. The fluoride concentration was determined. The area under the curve was calculated for each location and compared statistically. In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application. After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application. The difference between the baseline and the endpoint measurements was statistically significant. The fluoride concentration in the tongue coating remained at a higher level compared with the baseline for up to 120 minutes post-brushing. This may indicate that the tongue coating is a major reservoir for fluoride bioavailability. The results also indicate an unequal fluoride distribution in the oral cavity.
Highlights
Many factors have an impact on the biofilm formation, including host genetics, ethnicity, smoking, diet and its impact on the local pH2, local temperature in different sites of the oral cavity[3], age, environment, sexual behavior[4], and hormonal level[5]
The results are in accordance with previous studies that showed a dramatic increase in fluoride concentration after tooth brushing in the supernatant saliva, salivary sediment and plaque, followed by a decrease
The fluoride concentration after amine fluoride (AmF) application remained at a twofold higher level compared with the baseline in the tongue coating and in the palatal biofilm
Summary
Many factors have an impact on the biofilm formation, including host genetics, ethnicity, smoking, diet and its impact on the local pH2, local temperature in different sites of the oral cavity[3], age, environment, sexual behavior[4], and hormonal level[5]. Because of the differences in epithelial surface textures, the rheological properties of saliva and the composition of the oral biofilms in the various niches, the dynamics and distribution of proteins, polysaccharides and electrolytes such as fluoride may vary considerably. Individualized regimes for fluoride application in caries prevention in young children should be elaborated To achieve this goal, more detailed knowledge about the dynamics of fluoride distribution after its application into the oral cavity is necessary. Not much is known about the fluoride distribution after tooth brushing in the biofilm of different oral compartments It was the aim of this study to investigate the dynamic distribution of fluoride in different oral niches after the application of two different fluoride compounds. The secondary aims were to determine the variation in the fluoride concentration in two ways: between the different collection times and between both fluoride compounds at the different collection times
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