Abstract
Dynamics of Electrical Activity in Epileptic Brain and Induced Changes Due to Interictal Epileptiform Discharges
Highlights
Epilepsy is one of the major brain disorders affecting more than 64 million people worldwide out of which 3.4 million reside in the US
We proposed a technique to investigate functional connectivity (FC) network analysis for scalp EEG of patients with temporal lobe epilepsy (TLE)
Both Interictal Epileptiform Discharge (IED) and NIED segments are extracted and the following observations are made based on the results of the performed statistical tests: First, the most active region with the highest density of connections within an IED segment tend to be the one affected by the IED for the theta, alpha, and beta frequency sub-bands
Summary
Epilepsy is one of the major brain disorders affecting more than 64 million people worldwide out of which 3.4 million reside in the US. Results: a) The active frontal-temporal (FT) region as predetermined by the neurologists during an IED segment is found to be characterized by a statistically significant increase in the average local FC over the other FT region and over FT regions with the highest average local FC when using non-IED (NIED) segments of the same patient. This statistical significance is found for the theta, alpha, and beta sub-bands. The obtained results provide added confidence in utilizing FC maps as biomarkers for detecting IEDs
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