Abstract
Background Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) / drug-induced hypersensitivity syndrome (DIHS) are recognized as severe cutaneous adverse reactions (SCARs) usually induced by drugs. Due to the high risk of mortality, management of patients with SCARs requires rapid diagnosis. However, it is difficult to distinguish the early phase of SJS/ TEN and DIHS/DRESS from other ordinary types of drug-induced skin reactions. Therefore, there is a strong need of diagnostic markers for early stage of SCARs.
Highlights
Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) / drug-induced hypersensitivity syndrome (DIHS) are recognized as severe cutaneous adverse reactions (SCARs) usually induced by drugs
In this study, we focused on chemokine productions in DIHS/DRESS and SJS/TEN
Sera were obtained from 42 DRESS/DIHS patients associated with HHV-6 reactivation (n=31) and without HHV-6 reactivation (n=11), SJS/TEN patients, and patients with drug-induced maculopapular exanthema (MPE) in the acute and convalescent stage
Summary
Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) / drug-induced hypersensitivity syndrome (DIHS) are recognized as severe cutaneous adverse reactions (SCARs) usually induced by drugs. Dynamics of chemokines in severe drug hypersensitivity Hideo Asada1*, Kohei Ogawa1, Ayako Hasegawa1, Fumi Miyagawa1, Hideaki Watanabe2, Hirohiko Sueki2, Mikiko Tohyama3, Koji Hashimoto3, Yoko Kano4, Tetsuo Shiohara4, Hiroyuki Fujita5, Michiko Aihara5
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