Abstract
Summary. Bronchiscopic examination was performed in 103 patients, of them, 44 patients had chronic obstructive pulmonary disease (COPD) and 59 patients had atrophic bronchitis. Mild pulmonary hemorrhage was diagnosed in 24 patients with COPD and in 39 patients with atrophic bronchitis. Laser Doppler flowmetry was performed using a laser analyzer of capillary circulation LAKK-01 (Lazma, Moscow). After revision of bronchi, the optical guide with laser wavelength of 0.63 μm was run through biopsy channel of the bronchoscope and was located on the bronchial mucosa 1 cm higher the bronchial spur of the right upper lobe bronchus under visual control. The examination was done during 2 min. All patients with hemorrhage in bronchial mucosa had microcirculatory disorders of different character and severity. Character parameters of tissue perfusion significantly decreased. Mostly, the mean square deviation has been decreasing that indicated unsuccessful tissue perfusion. The amplitude of variations in VLF, LF and HF ranges increased indicating the increased capacity of venules and increased tone of precapillary vessels that also prevented adequate capillary circulation. Amplitudes of variables at CF range was noted that characterized arteriolar dilation.
Highlights
Бронхоскопия выполнена 103 больным, из них у 44 человек была хроническая обструктивная болезнь легких (ХОБЛ), у 59 – атрофичес кий бронхит
После осмотра бронхов световодный зонд от прибора с длиной волны лазерного излучения 0,63 мкм проводили через биопсийный канал брон хоскопа и под контролем зрения устанавливали на слизистой оболочке на 1 см выше шпоры правого верхнедолевого бронха
Microcirculation: its significance in clinical and molecular medicine
Summary
Изменения микрогемоциркуляции слизистой оболочки бронхов у больных с легочным кровотечением. Bronchiscopic examination was performed in 103 patients, of them, 44 patients had chronic obstructive pulmonary disease (COPD) and 59 patients had atrophic bronchitis. Изменения микрогемоциркуляции слизистой оболочки бронхов у больных с легочным кровотечением эритроцитов в зондируемом объекте и их скоростью. Регистрируемый при ЛДФ сигнал характеризует кровоток в микрососудах в объеме 1–1,5 мм ткани. Реги стрируемый при ЛДФ сигнал – параметр микроцир куляции (ПМ) – представляет собой интегральную характеристику подвижности эритроцитов в зонди руемом объеме ткани. Между тем высокая временная изменчивость микроциркуляции и связанные с ней колебания кровотока – это, по сути своей, объективные харак теристики уровня жизнедеятельности тканей. ЛДФ характеризует периодические изменения перфузии тканей кровью, протекающей с разной частотой и амплитудой.
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