Abstract
Background: Person infected with Severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) may develop virus specific IgG antibodies but antibody titers might decline over time, if antibody titer decline over time, chances of HCWs getting re-infected are higher.Methods: Here we assessed status of Anti SARS-CoV-2 antibodies in HCWs over a four months period by detection of anti-SARS-CoV-2-IgG antibodies using a semi-quantitative enzyme-linked immunosorbent assay (ELISA).Results: The present follow up study shows that during four months period sero-positivity in HCWs increased from 32% to 42%. Of 100 enrolled HCWs, 37 were RT-PCR positive at least once, of which only 31 were seropositive and six were seronegative. Of 63 RT-PCR negative individuals, one was seropositive. while two HCWs turned sero negative from sero positive and in five HCWs antibody titer increased.Conclusions: Although HCWs are at a greater exposure risk, the sero-prevalence in them at places where adequate preventive measures are taken, is comparable to that of general population.
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