Abstract
Methods Using 143 epidemiologically linked transmission pairs from a Zambian cohort we assessed: (1) the frequency of Gag polymorphisms circulating in the population, (2) if the polymorphisms could be associated with the infected individual’s HLA alleles, (3) the frequency at which polymorphisms are transmitted, and (4) the relevance of the transmitted polymorphisms (TP) to the newly infected individual’s HLA-I alleles.
Highlights
HIV immune escape is not random and follows a predictable mutational path in response to the HLA alleles carried by an individual
Using 143 epidemiologically linked transmission pairs from a Zambian cohort we assessed: (1) the frequency of Gag polymorphisms circulating in the population, (2) if the polymorphisms could be associated with the infected individual’s HLA alleles, (3) the frequency at which polymorphisms are transmitted, and (4) the relevance of the transmitted polymorphisms (TP) to the newly infected individual’s HLA-I alleles
We observed a median of 35 polymorphisms per chronically infected individual in Gag and 42% of these polymorphisms could be associated with the individual’s HLA (16% statistically linked, 26% epitope analysis)
Summary
HIV immune escape is not random and follows a predictable mutational path in response to the HLA alleles carried by an individual. Dynamics and frequency of Gag transmitted polymorphisms in Zambia From AIDS Vaccine 2012 Boston, MA, USA.
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