Dynamics Analysis of a Delayed HIV Infection Model with CTL Immune Response and Antibody Immune Response

Abstract

In this paper, dynamics analysis of a delayed HIV infection model with CTL immune response and antibody immune response is investigated. The model involves the concentrations of uninfected cells, infected cells, free virus, CTL response cells, and antibody antibody response cells. There are three delays in the model: the intracellular delay, virus replication delay and the antibody delay. The basic reproductive number of viral infection, the antibody immune reproductive number, the CTL immune reproductive number, the CTL immune competitive reproductive number and the antibody immune competitive reproductive number are derived. By means of Lyapunov functionals and LaSalle’s invariance principle, sufficient conditions for the stability of each equilibrium is established. The results show that the intracellular delay and virus replication delay do not impact upon the stability of each equilibrium, but when the antibody delay is positive, Hopf bifurcation at the antibody response and the interior equilibrium will exist by using the antibody delay as a bifurcation parameter. Numerical simulations are carried out to justify the analytical results.