Dynamical systems in computational psychiatry: A toy-model to apprehend the dynamics of psychiatric symptoms.

Abstract

These last years, scientific research focuses on the dynamical aspects of psychiatric disorders and their clinical significance. In this article, we proposed a theoretical framework formalized as a generic mathematical model capturing the heterogeneous individual evolutions of psychiatric symptoms. The first goal of this computational model based on differential equations is to illustrate the nonlinear dynamics of psychiatric symptoms. It offers an original approach to nonlinear dynamics to clinical psychiatrists. In this study, we propose a 3+1 dimensions model (x, y, z + f) reproducing the clinical observations encountered in clinical psychiatry with: a variable modeling environmental noise (z) on the patient's internal factors (y) with its temporal specificities (f) and symptomatology (x). This toy-model is able to integrate empirical or simulated data from the influence of perceived environmental over time, their potential importance on the internal and subjective patient-specific elements, and their interaction with the apparent intensity of symptoms. Constrained by clinical observation of case formulations, the dynamics of psychiatric symptoms is studied through four main psychiatric conditions were modeled: i) a healthy situation, ii) a kind of psychiatric disorder evolving following an outbreak (i.e., schizophrenia spectrum), iii) a kind of psychiatric disorder evolving by kindling and bursts (e.g., bipolar and related disorders); iv) and a kind of psychiatric disorder evolving due to its high susceptibility to the environment (e.g., spersistent complex bereavement disorder). Moreover, we simulate the action of treatments on different psychiatric conditions. We show that the challenges of dynamical systems allow to understand the interactions of psychiatric symptoms with environmental, descriptive, subjective or biological variables. Although this non-linear dynamical model has limitations (e.g., explanatory scope or discriminant validity), simulations provide at least five main interests for clinical psychiatry, such as a visualization of the potential different evolution of psychiatric disorders, formulation of clinical cases, information about attracting states and bifurcations, or the possibility of a nosological refinement of psychiatric models (e.g., staging and symptom network models).