Abstract
This paper aims to explore the dynamic characteristics of the post treatment human immunodeficiency virus (HIV) type‐1 model by proposing the theoretical frameworks. Distinct from the previous works, this study explores the effect of effector cells, loss of functional effector cells, and two types of anti‐retroviral therapies such as reverse transcriptase inhibitors (RTIs) and protease inhibitors (PIs) and also the effect of intracellular time delay. Based on the Routh—Hurwitz criterion and eigenvalue analysis, the stability of the proposed HIV‐1 model is analyzed. To reveal the significance of time delay, the Hopf‐type bifurcation analysis is performed. The optimal control algorithm is designed by choosing the antiviral therapies such as RTI and PI as control parameters. Numerical simulations are performed to validate the effectiveness of the proposed theoretical frameworks.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
