Abstract
Echo planar imaging (EPI) is one of the methods of choice in dynamic susceptibility contrast MRI (DSC-MRI) because it provides a sufficient temporal resolution. However, the relatively long readout duration of EPI often imposes limitations on increased spatial coverage or the use of multiple contrasts. To develop a DSC-MRI method using EPIK (EPI with keyhole) to provide dual-contrast (TE1 and TE2 ) information with a higher spatial coverage than EPI. To compare results from the community-standard EPI method and the proposed EPIK method. Prospective. One healthy subject and 17 brain tumor patients. 3 T/accelerated EPI and dual-contrast EPIK sequences. After an initial evaluation using healthy in vivo images, the use of the proposed method for DSC-MRI was verified with brain tumor patients. The parametric images (eg, CBF and CBV) and arterial input function (AIF), obtained from both the EPI and EPIK, were compared. The ratio of AIF peak height of the proposed method to that of EPI was computed. The ratio computation was also performed for the time-to-peak (TTP) in the AIF curves. From the obtained CBF and CBV maps, the tumor-to-brain (TBR) ratio was also calculated for each imaging method and the results were compared. For the same temporal resolution (1.5 sec), EPIK yielded dual-contrast (TEs of 13/33 msec) with an increased spatial coverage (24 slices) and less geometric distortions than EPI; EPI provided single contrast (TE of 32 msec) with 20 slices. The obtained parametric values (eg, AIF peak, TTP, and TBR) had similar characteristics between EPI and the proposed method. The dual-contrast data produced by EPIK in DSC-MRI allowed T1 -corrected parametric images without the need of second contrast injection and an enhanced estimation of the AIF. 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:628-640.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.