Abstract
In this paper, translocation events of single ellipsoid human serum albumin (HSA) with a solid glass nanopore have been investigated in detail by common resistive pulses. In particular, the translocation events can be classified into three main groups according to the significant difference in current pulse amplitudes. By adjusting the electric field of the nanopore upon changing applied conditions in voltage, pH, and pore size, the observation would be originally associated with dynamic rotation rather than increased size exclusion of HSA. Finally, the rotation angles of translocated HSA are determined by both experimental and theoretical studies.
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