Abstract
Chitosan and collagen are naturally-derived materials with multiple applications, but their mixtures present phase separation phenomena. This shortcoming in relation to the mixture processing and, obviously, the applications can be overcome by choosing the appropriate composition. Rheological methods have been used to study collagen - chitosan mixtures to highlight their compatibility conditions in solution. Through the use of oscillatory rheometry, the viscoelastic behavior of collagen-chitosan mixtures in 0.5M acetic acid solution was analysed. The storage modulus (G`) was used to describe the elasticity of the material, while the loss modulus (G`) provided information on the viscous behavior of the mixtures.
Highlights
Both chitosan and collagen are naturally-derived materials with multiple applications in the biomedical field
Being a biocompatible and biodegradable polymer, presenting antimicrobial activity, wounds healing properties and low immunogenicity, CS is of great interest in numerous medical applications, especially in tissue engineering and the preparation of microparticles and microspheres with entrapped drugs for controlled delivery [1,2,3,4,5]
Medical and pharmaceutical applications of collagen include its use in membranes, biodegradable films, wound and burns dressing, tumor treatment, and tissue engineering [6,7,8,9,10]
Summary
Both chitosan and collagen are naturally-derived materials with multiple applications in the biomedical field. Due to the presence of reactive amino and hydroxyl groups, CS can be modified too and is able to form complexes with acids and polycarboxilic acids. Being a biocompatible and biodegradable polymer, presenting antimicrobial activity, wounds healing properties and low immunogenicity, CS is of great interest in numerous medical applications, especially in tissue engineering and the preparation of microparticles and microspheres with entrapped drugs for controlled delivery [1,2,3,4,5]. Collagen (Col) is the most abundant structural protein found in the animal organs – in skin, tendon, cartilage and bone. Medical and pharmaceutical applications of collagen include its use in membranes, biodegradable films, wound and burns dressing, tumor treatment, and tissue engineering [6,7,8,9,10]
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