Abstract
The anatomical tenets of the quantal-vesicular hypothesis of neurotransmission are a 1:1 ration between numbers of releasable quanta and vesicles, a reciprocal response between vesicle and terminal membrane pools and constancy of the total membrane pool. We have used electrical stimulation and morphometry to study these relationships in the cholinergic presynaptic terminals of Torpedo electric organ. Our results show that during neurotransmission changes in vesicle numbers do not correlate with quantal release, vesicle and terminal membranes does not change in reciprocal fashion and total nerve terminal membrane does not remain constant. We conclude that these vesicular tenets of quantal release are not verifiable at the Torpedo electric organ junction.
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