Dynamic response and transfer characteristics of joint neurons in somatosensory thalamus of the cat

Abstract

1. The dynamic response of neurons sensitive to knee joint rotation in the cat somatosensory thalamus was studied during sinusoidal variation of joint angle. The input sine waves were applied with a precise voltage-controlled, electromechanical actuator. The average rate of discharge of a single cell was considered as the output parameter. Describing functions of the sensory system were extracted by correlation and spectral analysis techniques. The effects of anesthetic, bias angle, and excursion angle were investigated. Discrete and swept sinusoidal waveforms between 0.1 and 7.0 Hz were used as inputs.2. The majority of joint cells in the thalamus were rapidly adapting and had frequency-response curves that were characterized as highpass filters. Although the major features of the response curves for individual cells were very similar, they could not all be fit with a single transfer function. The describing function of all the rapidly adapting cells averaged together was well fit by a transfer function that could be termed velocity sensitive in the bandwidth between 0.1 and 6.5 Hz. Most of these phasic cells showed a phase-locking tendency, particularly at high frequencies.3. The dynamics of the response for the rapidly adapting cells was relatively independent of anesthetic, bias angle, and excursion angle. Threshold and saturation effects were exhibited by some cells for very small (less than 1 degree) and large (greater than 10 degrees) input amplitudes, respectively. In addition a few (17%) showed a bidirectional response, i.e., responded at both flexion and extension of the limb. The anesthetic had a strong effect in depressing the spontaneous discharge of the cells and seemed to change the character of the tonic response by introducing a bursting component.4. The transfer characteristic of the thalamic cells was found to be a single-pole low-pass filter plus a time delay. The optimized value for the filter was found to have a corner frequency of 6.0 Hz with a time delay of 6 ms.5. Of the knee joint sensitive cells, 17% were slowly adapting or tonic, and more tonic cells were found in the unanesthetized animals. Only one tonic cell was studied in detail, and its dynamic characteristics were similar to that of the slowly adapting joint receptors at low frequencies. In this respect the rapidly adapting and slowly adapting joint cells in the thalamus have strikingly different frequency-response curves, the former curves have a much steeper slope in the magnitude.6. The functional implications of these results and of other recent findings in relation to the probable role of joint receptors in mediating proprioception are discussed.