Abstract
An experiment was carried out to provide a data set specifically designed to allow the development of a model to describe the dynamic behaviour of radiocaesium in sheep tissues. A single intraruminal dose of 134CsCl was given to each of 15 Scottish Blackface ewes, aged 1–2 years. Radiocaesium activity concentrations were measured at various time intervals after dosing in blood, faeces and urine and, after slaughter, in a range of tissues and digestive tract contents. A first order compartment model was developed comprising nine compartments representing various organs and tissues in the body. Rate constants for the model were obtained by optimisation to the experimental results. A limited validation of the model was carried out by using it to calculate tissue transfer coefficients ( F f ) and biological half-lives ( 0.5) of radiocaesium in sheep. The values generated compare favourably with published figures. Applications for the model and constraints on its usage are examined along with possibilities for further development.
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